PRESS RELEASES
New Studies Examine the Use of ExactVu™ Micro-Ultrasound to Improve on Prostate MRI
Clinical evidence for micro-ultrasound is growing exponentially with publications from more than a dozen institutions reporting on more than 3,000 individual biopsy cases.
  • Lughezzani et al. 2020, European Urology Focus:
    The first blinded, prospective, level 1 evidence comparing micro-ultrasound to mpMRI.  Demonstrated identical detection rates for a micro-ultrasound-based biopsy procedure to an mpMRI-fusion-based biopsy procedure. 
  • Klotz et al. 2020, Canadian Urology Association Journal:
    The largest micro-ultrasound study to date with 1040 biopsy procedures across 11 institutions.  Micro-ultrasound demonstrated higher sensitivity and negative predictive value than mpMRI in this real-world registry study (p=0.03). 
  • Wiemer et al. 2020, European Urology Focus:
    Micro-Ultrasound targeted biopsy found a higher-grade cancer in 26% of patients compared to non-targeted samples and MRI targeted samples in this single-center experience. 
  • Cornud et al. 2020, European Radiology:
    A second-look study examining the visualization of mpMRI targets on micro-ultrasound.  When micro-ultrasound was normal, no significant cancer was found in this cohort, however micro-ultrasound did find sites of cancers missed by MRI in 24%. 
  • Socárras et al. 2020, Journal of Urology:
    The Madrid Protocol for transperineal biopsy using both Micro-ultrasound and MRI.  Micro-US found 10% additional csPCa that were missed by all other techniques. 
  • Claros et al. 2020, Journal of Urology:
    Real-time visualization of MRI targets on ExactVu yielded higher rate of csPCa than robotic fusion biopsy (p=0.02). 
  • Harland and Stenzl 2020, Prostate International: 
    A review article summarizing the state of the art in micro-ultrasound, covering comparison to mpMRI as well as utility for staging both prostate and bladder cancer. 
  • Sountoulides et al. 2021, Journal of Urology: 
    Systematic review and meta-analysis of 18 studies covering 1125 biopsy cases concluding that micro-ultrasound-guided biopsy provides comparable detection rates for csPCa diagnosis with the mpMRI-guided biopsy. 
  • Montorsi et al. 2021, Canadian Urology Association Journal:
    Letter responding to Klotz et al. 2020 CUAJ agreeing that micro-ultrasound has the “potential to become the first-level test for patients with a clinical suspicion of prostate cancer,” and confirming that their “initial experience has been similar to that reported” which suggests the results are reproducible and may have low variability between centers. 


2024

2023

2022

2021

2020

2019

2018

2017

2016

2015



© 2024 Exact imaging
ExactVu™, Exact Imaging™, PRI-MUS™, FusionVu™, Cognitive Assist™ and ExactVu Micro Doppler™ are trademarks of Exact Imaging.
ExactVu™ micro-ultrasound system is available for sale in the European Union (CE Mark), the United States (FDA 510(k) clearance), and in Canada (Health Canada license).