PRI-MUS™
Risk Identification
Protocol

SYSTEMATIC BIOPSY
PRI-MUS 1
Small regular ducts “Swiss Cheese”
PRI-MUS 2
Hyperechoic with/without ductal patches
TARGET SUSPICIOUS REGION
PRI-MUS 3
Mild heterogeneity or Bright Echoes in hyperechoic tissue
PRI-MUS 4
Heterogeneous “Cauliflower”, “smudgy or mottled” or Bright Echoes (”Starry Sky”)
PRI-MUS 5
Irregular Shadowing or Mixed-echo lesions or Irregular Prostate/PZ border
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PRI-MUS 1 & 2
For PRI-MUS 1 and 2 features — which are characteristically benign, the urologist would take a systematic biopsy.
PRI-MUS 3
PRI-MUS 3 characteristics could be supported by targeted or systematic biopsy, depending on the suspiciousness of the tissue.
PRI-MUS 4 & 5
For PRI-MUS 4 and 5 features, the urologist would target those areas which are highly correlated to significant disease.
*The initial PRI-MUS protocol was validated with data from 400 micro-ultrasound biopsy-based cineloops matched to pathological results.

** The accompanying study has been published in the Journal of Urology: Ghai, S. et al., “Assessing Cancer Risk in Novel 29 MHz Micro-Ultrasound Images of the Prostate: Creation of the Protocol of Prostate Risk Identification Using Micro-Ultrasound”, Journal of Urology, Paper In Press: June 2016, www.jurology.com/article/S0022-5347%2816%2900027-6/abstract

ExactVu™ micro-ultrasound system is available for sale in the European Union (CE Mark), the United States (FDA 510(k) clearance), and in Canada (Health Canada license).