PRI-MUS™ (prostate risk identification using
micro-ultrasound) is an evidence-based*
protocol for identifying sonographic features of
the prostate under micro-ultrasound to help
direct and target biopsies.
SYSTEMATIC BIOPSY
PRI-MUS 1
Small regular ducts "Swiss Cheese"
PRI-MUS 2
Hyperechoic with/without ductal patches
TARGET SUSPICIOUS REGION
PRI-MUS 3
Mild heterogeneity or Bright Echoes in hyperechoic tissue
PRI-MUS 4
Heterogeneous
“Cauliflower”, “smudgy
or mottled” or Bright
Echoes (”Starry Sky”)
PRI-MUS 5
Irregular Shadowing
or Mixed-echo
lesions or Irregular
Prostate/PZ border
CLICK on any image to enlarge
PRI-MUS 1 & 2
For PRI-MUS 1 and 2 features —
which are characteristically
benign, the urologist would take
a systematic biopsy.
PRI-MUS 3
PRI-MUS 3 characteristics could
be supported by targeted or
systematic biopsy, depending on
the suspiciousness of the tissue.
PRI-MUS 4 & 5
For PRI-MUS 4 and 5 features, the
urologist would target those
areas which are highly
correlated to significant disease.
*The initial PRI-MUS protocol was validated with data from 400 micro-ultrasound biopsy-based
cineloops matched to pathological results.
** The accompanying study has been published in the Journal of Urology: Ghai, S. et al., “Assessing
Cancer Risk in Novel 29 MHz Micro-Ultrasound Images of the Prostate: Creation of the Protocol of
Prostate Risk Identification Using Micro-Ultrasound”, Journal of Urology, Paper In Press: June 2016,
www.jurology.com/article/S0022-5347%2816%2900027-6/abstract
ExactVu™, Exact Imaging™, PRI-MUS™, FusionVu™, Cognitive Assist™ and ExactVu Micro Doppler™ are trademarks of Exact Imaging.
ExactVu™ micro-ultrasound system is available for sale in the European Union (CE Mark), the United States (FDA 510(k) clearance), and in Canada (Health Canada license).
